Binge ethanol consumption robustly increases circulating FGF21 levels in both humans and mice. FGF21 does not play a role in ethanol clearance which is physiologic effects of rotary blood pumps PDF same in WT and FGF21-KO mice. In mice lacking FGF21, in two models of ethanol consumption there was either excess mortality or excess hepatic damage and inflammation.
Författare: Peter Voitl.
The use of rotary blood pumps for assistance of advanced heart failure continues to increase with the growing prevalence of the disease itself and the availability of small and clinically applicable devices. These devices are used either as cardiac support prior to transplantation or to assist the recovery of the heart. As rotary blood pumps produce a non-pulsatile flow, several questions concerning the physiology of pulseless circulation are remaining. This book gives an introduction on cardiac support with blood pumps and covers the physiology of low-pulse and pulseless circulation under rotary assist device support according to the literature.
These data suggest the FGF21 may have potential therapeutic value for alcoholic liver disease. In humans, repeated episodes of binge drinking can lead to liver damage and have adverse effects on other organs such as pancreas and brain. Long term chronic consumption of ethanol can also result in progressive alcoholic liver disease and cirrhosis. We adapted this paradigm to evaluate the acute response to ethanol in mice. Serum ethanol peaked at 1 h in both species and was cleared by 6 h. Ethanol clearance was the same in WT and FGF21-KO mice, indicating that FGF21 does not play a major role in ethanol metabolism in a binge paradigm.
However, FGF21 does not play a role in acute ethanol clearance. In contrast, chronic ethanol consumption in the absence of FGF21 is associated with significant liver pathology alone or in combination with excess mortality, depending on the type of diet consumed with ethanol. 6Present address: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy. 7Present address: 1Globe Health Institute, Norwood MA 02062, USA. Comparison of continuous-flow and pulsatile-flow left ventricular assist devices: is there an advantage to pulsatility?
Chief, Department of Cardiovascular and Thoracic and Surgery, University of Louisville, 201 Abraham Flexner Way, Suite 1200, Louisville, KY 40202, USA. CFVADs have demonstrated improved reliability and durability. Methods: In this review, we compared the outcomes of CFVADs and PFVADs and examined the need for arterial pulsatility for the future generation of mechanical circulatory support. Results: CVADs offer advantages of smaller size, increased reliability and durability, and subsequent improvements in survival. However, with the increasing duration of long-term support, it appears that CFVADs may have specific complications and a lower rate of left ventricular recovery associated with diminished pulsatility, increased pressure gradients on the aortic valve and decreased compliance in smaller arterial vessels. Conclusions: Given the relative advantages and disadvantages of CFVADs and PFVADs, the ultimate solution may lie in incorporating pulsatility into current and emerging CFVADs whilst retaining their existing benefits.
Future studies examining physiologic responses, end-organ function and LV remodeling at varying degrees of pulsatility and device support levels are needed. Accepted for publication Aug 23, 2014. Previous studies have compared CFVADs with PFVADs and have presented differing outcomes. It is important to understand and examine the outcome differences between CFVAD and PFVAD in order to further advance LVAD therapy. The objective of this review is to compare the outcomes of CFVADs and PFVADs, and examine the need for arterial pulsatility to minimize CFVAD associated complications and to improve the rate of myocardial recovery. Pulsatility The arterial pulse is an important part of our cardiovascular system. Human cells can detect and are adapted to the cyclic changes of pressure and flow.